Pathology EMQ template

Your Name: Hugh Ip

Your Identifier:

Theme: Haemolytic anaemias

OPTION LIST

A	Blood transfusion	I	Splenectomy
B	Bone marrow transplantation	J	Stop the offending drug
C	Corticosteroids	K
D	Folate supplementation	L
E	Gene therapy	M
F	Immunosuppression	N
G	Keep the patient warm	O
H	Monoclonal antibodies	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 16 year old boy presented with symptomatic anaemia. Following investigation, he was diagnosed with hereditary spherocytosis. A raised bilirubin and gallstones were detected. What is the most appropriate treatment?

2. A patient, presenting with anaemia and jaundice, was admitted for investigation. She received a positive result for the Coombs’ test. The antibody reacted more strongly with the red cells at 37°C than 4°C. She is not taking any medications. What is the first treatment she should receive?

3. Patients with haemolysis are at risk of a particular complication resulting from the high turnover of erythrocytes. How can this be prevented?

4. A pregnant woman presented with symptoms of anaemia. Laboratory findings indicated a haemolytic anaemia. She had just begun taking methyldopa for hypertension. What is the most appropriate treatment?

5. Paroxysmal nocturnal haemoglobinuria is a chronic disorder. What is the most appropriate supportive treatment for one of its major clinical signs?

ANSWERS

1. I

2. C

3. D

4. J

5. A